To make a mess of; to untidy, disorder, soil, or muss.
The afternoon breeze messed up my hair.
To cause a problem with; to introduce an error or mistake in; to make muddled or confused; spoil; ruin.
The change messed something up, and it's not working anymore.
To botch, bungle; to perform poorly on.
Well, I messed up my solo, but otherwise it was a good concert.
To make a mistake; to do something incorrectly; to perform poorly.
He has a hard time getting started because he's afraid he'll mess up.
To cause (another person) to make unwanted mistakes in a given task, usually through distraction or obnoxious behavior.
Stop bumping me! You keep messing me up!
To damage; injure.
He messed up his elbow at the track meet.
To manhandle; beat up; rough up.
Her brother's friends messed him up a little after he cheated on her.
To discombobulate, utterly confuse, or confound psychologically; to throw into a state of mental disarray.
That girl totally messed me up, man. I'm not sure who I am anymore.